Why does chemotherapy affect my toenails?

During chemotherapy, you may experience several changes in your nails. They may look bruised, develop blemishes such as lines or indentations, become dry and thin or grow more slowly. Your nails are likely to break more easily, your cuticles may fray, and sometimes a nail may fall off. These side effects are temporary, but they can lead to a more serious infections of the toenails.