Extracellular Matrix

Amniotic tissue is an abundant source of collagen that provides an extracellular matrix to act as a natural scaffold for cellular attachment in the body. Collage provides a structural tissue matrix that facilitates, among other things, cell migration and proliferation in vivo. Developed using a technique that morselizes the amnion in an effort to preserve its structural properties in an injectable form. This morselized tissue matrix includes the residual proteins, carbohydrates, hyaluron acid, growth factors and other chemical compounds natrually present in amniotic fluid and tissue ot provide an in vivo wound covering that is derived from those components essential for fetal growth and development. Clinicians have used amniotic tissue for over a century as a biologic dressing in a broad range of therapeutic applications. It has been generally recognized as a versatile wound covering with published clinical results cited extensively in the literature.

Unique Attributes of Amion

During pregnancy, amniotic membrane, fluid and cells act as a biologic system whose primary function is to (i) protect the fetus; and (ii) aid in fetal growth and development. In addition to its structural properties, the placental membrane and amniotic flud have been found to contain a rick source of proteins, cytokines, growth factors and other chemical compounds, all of which are essential for fetal growth and development.

Amniotic fluid also contains multipotent cells that are capable of differentiating into all three germ layers of the human body. Specifically, amniotic fluid derived stem cells have been shown to be broadly multipotent, capable of differentiating into adipogenic, endothelial, neurogenic and hepatic cell lineages. While the primary function of AmnioMatrix is to provide a structural tissue matrix to cover and protect the wound, the presence of residual multipotent cells naturally present in amnion may provide ancillary clinical benefits by enhancing the body's natural regenerative process.

Consider the source:

- Tissue recovered from live, healthy donors during childbirth

- Crypreserved liquid allograft derived from fetal afterbirth tissue and cells

- Collagen present in amnion provides an extra-cellular matrix to act as a natural scaffold for cellular attachment in the body.

- Amnion derived extracellular matrix includes proteins, growth factors and residual multipotent cells naturally present in amion.

- AmnioMatrix can be injected or applied directly to the surgical site. It is cryopreserved to facilitate an extended shelf life and is easy to handle in the operating room.

- Processed and packaged at an FDA registered tissue bank.

- Meets or exceeds all applicable industry standards for processing of human cellular and tissue based products.

- Immune Privileged. Amniotic membrane is a unique human tissue in that it rarely evokes an immune response in the human body. This unique attribute has been described in numerous clinical studies and scientific journals and has led to the characterization of the placental organ as "immune privileged." The unique biological structure of amniotic tissue, coupled with the low risk of an immune response, makes AmnioMatrix an ideal choice for homologous therapeutic use.


Dr. Craig H. Thomajan, DPM, FACFAS, FAENS
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Founder and Managing Partner of Austin Foot and Ankle Specialists